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Our Founding Story

A story of loss, resilience, and the future of reconstruction.

Katharine Derrey, founder of the Hopewell Foundation for Regenerative Medicine
Katharine Derrey, Founder & CEO

The Hopewell Foundation for Regenerative Medicine wasn't born in a lab. It was born from pain, loss, and the realization that patients deserve better than the options they're given today.

This is where that realization began.

At 27, I underwent what I believed would be a routine nasal procedure. Like many patients, I didn't fully understand how complex the nose is, how delicate, how interconnected, and how even small changes can have lasting consequences.

At the time, my life felt stable. Predictable. Full of forward motion.

I went into surgery expecting a straightforward outcome and a relatively quick recovery.

But when the cast finally came off, I knew something was wrong.

As the swelling slowly subsided, the truth became unavoidable: most of my nose was gone.

In an instant, everything changed.

What followed wasn't a simple revision. It became a yearslong process of reconstruction marked by uncertainty, physical pain, and the ongoing effort to hold onto a sense of identity that no longer felt intact.

I was told the only way to rebuild my nose was to harvest cartilage from my rib. The explanation was clinical, but the reality was difficult to accept, sacrificing healthy tissue from one part of my body in an attempt to repair another.

It didn't feel like a choice. It felt like the only path forward.

The surgery was grueling. The recovery was long and painful. But the deepest impact wasn't physical.

It was psychological.

Because when your face changes, your relationship with the world changes with it.

How you see yourself. How you're seen by others. How safe you feel in your own body.

I remember looking in the mirror and feeling a profound sense of loss, not just of appearance, but of recognition. As if the person I had been was no longer fully there.

And even after enduring all of that, the outcome was not stable.

The cartilage warped. My breathing worsened. Structural damage developed on one side of my nose.

At that point, this was no longer cosmetic. It was functional. It affected something as basic, and as essential, as the ability to breathe.

And still, the system failed.

Insurance restricted me to in network providers, many of whom acknowledged that my case required highly specialized, out of state reconstructive care.

My claims were denied anyway.

I was left paying out of pocket for someone else's mistake while trying to manage the physical, emotional, and financial consequences at the same time.

Over time, I began to understand that my experience wasn't just personal, it reflected a broader gap in medicine.

We still do not have adequate solutions for complex reconstruction.

Patients are routinely asked to sacrifice healthy tissue from their ribs, foreheads, and other parts of their bodies because better options do not yet exist, or are not accessible.

And one question kept returning, impossible to ignore:

That question is what led me to regenerative medicine.

Not because innovation should replace surgeons or the foundations of modern care, but because patients deserve solutions that restore, rather than redistribute harm.

Solutions that are safer. More precise. More humane.

Over the past five years, I've had to come to terms with the permanence of what happened to me. One of the hardest truths has been accepting that someone else's mistake is something I will carry, visibly, for the rest of my life.

Experiences like that change you.

But they can also give you direction.

Not just to tell a story, but to help change what comes next.

Because progress in medicine should not happen in isolation.

It should be shaped by the people who live with its outcomes.

Why is this still the best we can offer?

Hopewell was built from that direction.

And no one should have to sacrifice one part of their body just to try to repair another.